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The results consistently show excess mortality in patients treated with combined levodopa and selegiline.Revised diagnosis,autonomic or cardiovascular events,or drug interactions could not explain this finding, but falls and possible dementia were more common in arm 2.The results do not support combined treatment in patients with newly diagnosed Parkinson' s disease.In more advanced disease,combined treatment should be perhaps be avoided in patients with postural hypotension,frequent falls,confusion,or dementia. |
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